Article published on the 2009-03-03 Latest update 2009-03-04 09:20 TU
"There are a number of issues we have between Syria and the United States as well as the larger regional concerns that Syria obviously poses," she said after her meeting with Israeli Foreign Minister Tzipi Livni.
Clinton said that a two-state solution between Israel and Palestine is "inescapable". She is also holding talks with right-wing Prime Minister-designate Benjamin Netanyahu.
Netanyahu, who also held the top position in 1996, was against the Oslo peace process, and analysts indicate that he will not push for establishing a Palestinian state.
He has said that he will focus on building up the nearly non-existent Palestinian economy.
When asked, Clinton said that she looked forward to working with Israel's new government, but said, "We might have opinions that we will express from time to time."
Clinton has asserted that the US would pursue "aggressive diplomacy".
But there need to be more changes, says journalist Peretz Kidron.
"If [US President Barack] Obama merely continues the Bush policy of more or less backing anything and everything that Israel does or at least ignoring the more flagrant violations of human rights and international law, that will be fine from the point of view of the Israeli government," he told RFI.
When asked if US pressure could be effective in the peace process, Kidron says, "If it's a far-right coalition with strong opposition in the Knesset [Israeli parliament], and really effective pressure is applied by the US, (the coalition] is likely to break."